This series forms the largest part of the collection and is contained in Boxes 2.1 to 2.11. It is a comprehensive look at Victor Lowe's faithful study of the work and life of Alfred North Whitehead which he began as a graduate student at Harvard in 1929 and continued until his death in 1988.

Topics in Boxes 2.1 and 2.2 are the "Cambridge Years," "Whitehead Family Research," " Understanding Whitehead," and the "Harvard Years." Topics in Boxes 2.3 and 2.4 are "The British File," and "Subjects in Whitehead's Philosophy." More "Whitehead Family" research is also in Box 2.4. The topic in Box 2.5 is "Bertrand Russell." The topic in Boxes 2.6 and 2.7 is "Writers on Whitehead." The topic is Boxes 2.8 and 2.9 is "American Research: Correspondence and Interviews." Box 2.10 contains reprints of articles by Alfred North Whitehead and Victor Lowe. Victor Lowe's two-drawer card file (Box 2.11) which includes references and notes labeled "British" and "American," corresponds to his research material filed in folders.